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A Kinase Inhibitor Phenotypic Screen Using a Novel Multiplex T Cell Activation Assay

T cells play a critical role in adaptive immune responses including pathogen elimination and tumor immunosurveillance. Activation of the T cell receptor (TCR) pathway in naive and effector T cells leads to T cell activation, proliferation, and cytokine production.

Modulating the TCR signaling pathway using biologics, small molecules or genetic engineering is highly relevant to many therapeutic areas including cancer immunotherapy, adoptive cell therapy, vaccine development and autoimmune disease. The development of these drugs and therapies require the routine use of assays to profile T cell function and health.

Learn about a novel assay that was used to evaluate a library of kinase inhibitors by simultaneously measuring:

  • Activation markers
  • Cell proliferation
  • Cytokines