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Cyclic Peptide Quantitation in Human Plasma

MicroLC-MRMHR Workflow for Cyclic Peptide Quantitation in Human Plasma

In biotherapeutic development, decreased drug doses and limited sample volumes require higher quantification sensitivity, while the complexity of biological matrices calls for the need of assay selectivity improvement.

High-resolution accurate mass spectrometry (HRAMS) can efficiently differentiate the target analyte from the interference molecules with similar m/z, providing better selectivity than unit resolution quantitation methods.

Download this app note to discover a novel HRAMS method that:

  • Shows improved quantitation sensitivity
  • Can dramatically reduce the biological interferences in human plasma
  • Allowed the detection of the cyclic peptide desmopressin at 1 pg/mL