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Determine Kinetics Earlier in the Drug Discovery Process

Determine Kinetics Earlier in the Drug Discovery Process
credit: iStock

Determination of accurate binding kinetics and affinity along with other critical quality attributes (CQAs) plays an ever-increasingly important role in identifying and isolating therapeutic molecules.

During high-throughput screening (HTS), drug candidates are typically prepared as a single concentration and injected across the target. A major restriction of this approach is that no quantitative information about kinetic parameters can be determined and that any hits need subsequent characterization using a more laborious multi-concentration assay.

This app note highlights how reliable kinetics for high-affinity interactions can be obtained from single injections.

Download this app note to learn more about: 

  • Generating accurate binding kinetics from a single concentration gradient
  • Reducing sample preparation with lower analyte concentrations
  • A cost-effective method for the early drug discovery process

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