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Distinguishing Oxidative Impurities From Ionizable Lipids Using Electron Activated Dissociation

Lipid nanoparticles (LNPs) comprised of ionizable lipids can be used to deliver oligonucleotides to work as therapeutics or to stimulate the immune system. Detailed and sensitive characterization of the ionizable lipid and its related impurities is necessary to ensure quality, however, obtaining the level of detail needed is challenging with current LC-MS-based methodologies.

Download this app note to discover how electron activated dissociation can:

  • Obtain in-depth structural characterization of singly charged, ionizable lipids and related impurities
  • Decrease risk of missing critical low abundance impurities
  • Increase confidence in product quality assessment