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Quantification of Host Cell Protein Impurities Using the Agilent 6495C Triple Quadrupole LC/MS

Host cell protein (HCP) impurities are low-level protein impurities derived from the host organisms during the biopharmaceutical manufacturing process. Due to their potential to affect product safety and efficacy, HCPs must be monitored and controlled in drug products according to regulatory requirements.

Download this application note to discover a full workflow solution for monitoring HCP impurities, including:

  • Sample preparation
  • Successful use of LC/MS
  • Data processing