Residual Solvents in Pharmaceuticals by USP Chapter <467> Methodology
Method USP 467 classifies residual solvents into three classes according to toxicity; class 1 solvents are to be avoided unless there is strong justification, class 2 solvents are those that should be limited due to toxicity concerns, class 3 solvents are less toxic and ideally used were practical.
This application note explains:
- How to measure solvents and by products with headspace gas chromatography
- FID performance at the concentration limits for solvents