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Application Note

Size Matters in Uncle's Sizing With Thermal Ramp App

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Application Note

Size Matters in Uncle's Sizing With Thermal Ramp App

DLS is a highly sensitive tool for measuring the hydrodynamic size of proteins in solution and can quantify changes in size or aggregation in response to a thermal ramp. Monitoring thermal stability of a protein by DLS is one way a multi-modal instrument like Uncle can collect several different pieces of stability data in a single experiment.

In this application note, you will discover:

  • How size and aggregation respond to thermal ramps and formulation changes
  • The advantages of using two kinds of light scattering as detection methods
  • How to inform your biologic formulations with these methods
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