Size Matters in Uncle's Sizing With Thermal Ramp App
Application Note Oct 21, 2019
DLS is a highly sensitive tool for measuring the hydrodynamic size of proteins in solution and can quantify changes in size or aggregation in response to a thermal ramp. Monitoring thermal stability of a protein by DLS is one way a multi-modal instrument like Uncle can collect several different pieces of stability data in a single experiment.
In this application note, you will discover:
- How size and aggregation respond to thermal ramps and formulation changes
- The advantages of using two kinds of light scattering as detection methods
- How to inform your biologic formulations with these methods