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The Glycome and Cancer
ArticleThe surfaces of cancer cells frequently express different types of glycoproteins, and because healthy cells don’t express these molecules (or do so at a much lower level), there has been significant interest in them as potential anticancer targets. Recent advances suggest we are about to see a resurgence in cancer glycomics.
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Mass Spectrometry in Biopharmaceutical Discovery
ArticleBiotherapeutics now makes up 25% of new drugs approvals. Their efficacy and safety are highly dependent on their structures, which are complex, heterogeneous and subject to modification. Advances in mass spectrometry are allowing more information on higher order structure and new imaging techniques are even providing insights into how biological drugs behave in vivo.
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Exploiting the Tumor Microenvironment for Cancer Therapeutics
ArticleIt’s more than a century since Paget first proposed the ‘soil and seed’ hypothesis in cancer, providing evidence that the environment surrounding a tumor is as important as the tumor itself. Research in this area has gathered momentum and it’s now the focus of intense research efforts.
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Relaxing the Tension Between Publishing and Patenting: Practical Hints and Tips
ArticleIn Part 1 we outlined some patent-related ramifications of publishing your research and development prior to filing a patent application. This second part provides you with some practical hints and tips for drafting your paper, helping you to avoid potential issues that can arise.
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Relaxing the Tension Between Publishing and Patenting: The Legal Basis for Tension
ArticleTension can be felt between the desire to publish and the need to patent, especially in commercially savvy environments such as medical technology and pharmaceuticals. This article discusses the legal rationale behind why publishing early can hinder future patenting opportunities and provides practical tips for avoiding this situation.
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Novel Biotherapeutics for the Treatment of Cancer
ArticleImmunotherapies might be stealing the show in cancer biotherapeutics, but it would seem that combining them with other biological agents – DNA or viruses, for example – is the way to seeing dramatic successes in more cancer patients.
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Discipline Convergence and the New Manufacturing Paradigm
ArticleIn many industries, curiosity-driven research is being replaced by purpose-driven research, as scientists must satisfy market-led specifications. Successful predictive science depends on seamless collaboration, unified workflows, comprehensive knowledge, and standardized data that is available and understandable in context.
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Types of Pollution: Have You Considered Pharmaceutical Waste?
Article
Despite regulation and legislation regarding the methods by which pharmaceutical companies must treat waste water, reports indicate that manufacturers are continuing to discharge untreated or inappropriately treated waste into the environment. The problem is having devastating impacts on human health, the environment and antimicrobial resistance is soaring.
Reprogramming and iPSC Formation - Then and Now
ArticleThe ability to create stem cells from non-embryonic cells, through the process of reprogramming, lifted the ethical hindrance and is driving stem cell research in a new direction at a rapid pace.
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Microfluidic Method Identifies Rare Antibodies with Therapeutic Potential
ArticleA novel microfluidic platform, able to rapidly isolate and identify rare antibodies from a vast repertoire of human B cells, has been developed by scientists. This technology could possess the ability to support and enhance the development of novel vaccines and biopharmaceuticals in the future.
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