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Biologic Production and Host Cell Proteins

Antibodies
Credit: iStock

Biologic therapies have transformed modern medicine, but their production in mammalian systems, particularly Chinese hamster ovary (CHO) cells, introduces challenges related to host cell proteins (HCPs). If not adequately managed, these impurities can compromise drug safety and efficacy.


This article examines the complexities of HCP contamination in biologic manufacturing. Continue reading to discover the importance of advanced analytical techniques for HCP detection and strategies to mitigate their impact.

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