A Customized XF Workflow for Detection and Characterization of Mitochondrial Toxicity
Many different classes of drugs can cause drug-induced mitochondrial toxicity, which may result in brain, cardiac, liver, muscle and/or kidney injury. This means that sensitive, specific and accurate detection of mitochondrial toxicity is a key consideration during the development of therapeutic compounds.
Download this app note to learn more about:
- How to measure the mitochondrial toxicity and identify the mode of toxicity with a single assay by using Mito Tox Index (MTI)
- Examples of screening experiments using a 240-compound library with Z’ > 0.5
- Software tools that simplify assay template creation and data analysis for screening and dose-response studies
