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The Growing Importance of Mitochondrial Toxicity Assessment in Drug Discovery and Development

The pharmaceutical industry spent decades bringing several drugs to the market, only to be withdrawn due to liver failure, associated with mitochondrial toxicity. The tests available at the time could not detect this toxicity and drug developers were presented a market withdrawal risk.

Many scientific leaders recognized the potential to assess mitochondrial toxicity through the direct functional measurements of mitochondrial respiration, using fluorescent probes, sensitive to oxygen, which led to the introduction of real-time assays of mitochondrial toxicity.

Download this case study to learn more about:

  • Why mitochondrial toxicity testing are so important
  • The introduction of real-time assays of mitochondrial function
  • An example of how pharmaceutical companies act to prevent potentially toxic compounds from slipping through in their early drug discovery process