Conventional mass spectrometry (MS) often depends on chromatography to separate complex mixtures prior to detection, but these additional preparation steps can be time consuming and resource intensive, creating significant workflow bottlenecks.
This infographic explores how chromatography-free MS bypasses traditional separation steps, enabling faster, simpler, and more cost-effective analysis without compromising data quality.
Download this infographic to discover:
- How chromatography-free MS accelerates analytical workflows
- Key ionization and sample preparation techniques driving efficiency
- How chromatography-free MS is advancing applications across research, clinical, and industrial applications
Conventional mass spectrometry (MS) often relies on chromatography to
separate complex mixtures before detection, which can be time consuming
and resource intensive. Chromatography-free MS bypasses this step, enabling
faster, simpler, and more cost-effective analysis. This infographic will explore
chromatography-free MS approaches and highlight key technologies, recent
innovations, and real-world applications.
KEY TECHNOLOGIES STREAMLINING MS ANALYSIS
Chromatography-free MS replaces the separation step with innovative delivery and ionization techniques. This facilitates direct
analysis of samples in their native state, maximizing throughput and sensitivity while reducing time required for preparation.
.
Direct infusion (DI-MS)
The sample is directly delivered into a
high-resolution mass spectrometer.
Solid phase extraction (SPE-MS)
The sample is cleaned and concentrated
using a solid adsorbent before MS.
SAMPLE PREPARATION AND INTRODUCTION METHODS IN CHROMATOGRAPHY-FREE MS
Infrared matrix-assisted laser
desorption electrospray
ionization (IR-MALDESI)
Uses laser desorption followed by
ESI-like ionization. Desorption electrospray
ionization-MS (DESI-MS)
A charged electrospray extracts
and ionizes surface molecules.
AMBIENT IONIZATION IN MS
Ambient MS ionization enables samples to be analyzed in their native state, under open-air conditions
(i.e., not in a vacuum), with minimal sample preparation.
Direct analysis in real
time-MS (DART-MS)
Uses helium and corona discharge—
a high-voltage, ion-generating
electrical discharge—to directly
ionize solids, liquids, or gases at
atmospheric pressure.
The latest breakthroughs in chromatography-free MS focus on optimizing the
interface between the sample and the mass spectrometer. By utilizing advanced
surface chemistries and automated delivery, these technologies offer enhanced
sensitivity and speed while minimizing residue contamination.
Chromatography-free mass spectrometry is transforming analytical workflows by removing the bottleneck of
traditional separation steps. With minimal sample prep and automation, it delivers rapid analysis—even for
non-experts. Advanced ionization methods and emerging high-throughput tools make chromatography-free
MS a versatile solution across research, clinical, and industrial fields.
