Fundamentals of Therapeutic Drug Monitoring: Definition, Importance and Methods
Therapeutic drug monitoring (TDM) is the measurement of circulating concentrations of a drug to adjust its dosing regimen, so as to reach a defined target exposure associated with optimal efficacy and minimal toxicity. Samples are collected at a known time relative to the administration of the last dose. Early development of TDM is largely attributed to University of California researchers Lewis Sheiner and Stuart Beal, who created NONMEM, a software for pharmacokinetics modeling.
Download this listicle to discover answers to key questions such as:
- Can therapeutic drug monitoring be used for all drugs?
- Which drugs are currently monitored using TDM approaches?
- What analytical methods are used for therapeutic drug monitoring?