Host Cell Protein Analysis in 2020

Listicle

Last Updated: November 5, 2020

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During biotherapeutic production, a range of impurities and variants can be generated, including host cell proteins (HCPs). HCPs present a safety risk as they can produce immunogenic responses and may reduce drug efficacy. To meet regulatory criteria, developers must verify that HCPs have been reduced to an acceptable level.

To keep up with the rapidly growing biotherapeutic industry, the large analytical toolkit of techniques for HCP analysis has continued to evolve.

Download this listicle to discover five recent approaches which help to improve the separation and detection of HCPs, using technologies such as:

One-dimensional liquid chromatography
Advanced biosensors
Host cell line engineering

Meet the Author

Michele Trott, PhD

Michele Trott (nee Wilson) is a New Zealand-based science writer who pursues freelance writing projects alongside her in-house role as a scientific content writer at Izon Science. After completing her PhD (Endocrinology) at Lincoln University (NZ), Michele began pursuing her science writing career with Technology Networks in the UK. There, she spent 12 months covering a maternity leave role as a science editor, and managed the cell science, biopharma and diagnostics communities. Upon her arrival back in NZ, Michele established “Choice Science Writing” and became a full-time freelance science writer, working with life science marketing agencies, biotech companies – and of course, Technology Networks – to produce engaging articles and blog posts. In April 2021, she took up the opportunity to join the team at Izon Science, a company that enables the precise separation and analysis of extracellular vesicles and other nanoparticles.