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Nanoparticles Carrying Immune-Signaling Molecules Designed To Support Cancer Immunotherapy
Researchers have developed lipid nanoparticles that can carry immunity-triggering molecules into macrophages in the liver. Using mice, the team was able to demonstrate that this approach could convert the immune status from immunologically "cold" to "hot" helping to reduce resistance to anti-PD-1 antibody treatment.
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Discovering New Targets for Cancer Vaccines
Research conducted by a team from MIT suggests that vaccinating against certain proteins found on cancer cells could help to enhance the T-cell response to cancer cells.
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A New Intranasal Subunit Vaccine for COVID-19
Navin Varadarajan, University of Houston M.D. Anderson Professor of Chemical and Biomolecular Engineering, and his colleagues, are reporting in iScience the development of an intranasal subunit vaccine that provides durable local immunity against inhaled pathogens.
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SARS-CoV-2 Evolves To Be More Infective During In Vitro Growth
Researchers at the University of Alabama at Birmingham have published a foundational study where they asked a simple question: Which mutations predominate when the SARS-CoV-2 virus that causes COVID-19 is grown in successive generations — called passages by virologists — in tissue culture?
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Typhoid Vaccine Safe for Infants and Young Children in Malawi
A new study, published in the New England Journal of Medicine, finds a single dose of typhoid conjugate vaccine (TCV) – the only typhoid vaccine licensed for children as young as 6 months – is safe and 84 percent effective in protecting against typhoid in Blantyre, Malawi.
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Improving the Treatment of Leukemia With Targeted Approaches
Research conducted by scientists from the University of Basel has shown that it may be possible to improve the treatment of leukemia by additionally inhibiting a specific signaling pathway.
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Immune System Memory Stays Strong 6+ Months After Moderna Vaccine
A new study from La Jolla Institute for Immunology (LJI) scientists helps answer the question: how long does immunity against COVID-19 last in vaccinated people?
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Researchers Unravel the Inner Workings of DNA Repair Enzymes
Scientists are exploiting the latest advances in single-molecule detection to explore the enzymatic activity involved in gene repair. Further research in this area could lead to technologies for targeted gene repair and drug development.
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Antioxidant Fails To Slow Parkinson’s Disease Progression in Clinical Trial
The hypothesis that raising the brain levels of the natural antioxidant urate could slow the progression of Parkinson’s disease (PD) has been disproven by researchers at Massachusetts General Hospital (MGH).
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Molecular Code Designed To Boost Immunotherapy Response
Researchers have designed a synthetic molecular code to improve the response of some cancer patients to immunotherapy treatments, by increasing the number of immune cells and improving their longevity.
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