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Simple Addition to COVID-19 Vaccines Could Enhance Their Effectiveness
A simple addition to injected COVID-19 vaccines could enhance their effectiveness and provide “border protection” immunity to supplement antibodies in the bloodstream.
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Intranasal COVID-19 Vaccine Reduces Disease Severity and Blocks Transmission
Lancaster University Scientists have developed a COVID-19 vaccine that can be delivered via a nasal spray. In a preclinical trial, the vaccine was found to decrease both disease severity and transmission of the virus. The study results are published in the journal iScience.
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Two-Armed Molecule Depletes Cancer-Protecting Cells Inside Tumor
Researchers have developed a two-armed molecule that can target both CLTA-4 and CD47 on regulatory T cells to hone in on tumors and enhance antitumor immunity.
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Monoclonal Antibody Prevents Malaria in Clinical Trial
One dose of a new monoclonal antibody discovered and developed at the National Institutes of Health safely prevented malaria for up to nine months in people who were exposed to the malaria parasite.
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New Platform Quickly Identifies Mutations in the SARS-CoV-2 Virus
Researchers have developed a platform that can quickly identify common mutations on the SARS-CoV-2 virus that allow it to escape antibodies and infect cells. This research marks a major step toward successfully developing a universal vaccine for deadly global viruses.
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Trial Will Test Third Dose of COVID-19 Vaccine in Transplant Recipients
A pilot study has begun to assess the antibody response to a third dose of an authorized COVID-19 mRNA vaccine in kidney transplant recipients who did not respond to two doses of the Moderna or Pfizer-BioNTech COVID-19 vaccine.
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Machine Learning Finds Powerful Peptides That Could Improve Drug Delivery
Researchers from MIT have harnessed machine learning approaches to discover powerful peptides that could improve a gene therapy designed to treat Duchenne muscular dystrophy.
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Sugar-Binding Proteins a Potential Pan-Variant Therapeutic?
Researchers identify two sugar-binding proteins that impede the viral entry of circulating SARS-CoV-2 variants.
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New CRISPR Technique Corrects Cystic Fibrosis in Human Stem Cells
Researchers have corrected mutations that cause cystic fibrosis in cultured human stem cells. The study shows that prime editing is safer than the conventional CRISPR/Cas9 technique.
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Women Underrepresented in Cardiovascular Clinical Trials
Women remain underrepresented in cardiovascular clinical trials despite guidelines and legal requirements developed almost 30 years ago to ensure broader inclusivity. This lack of representation can limit availability of treatment data on the number one killer of women worldwide, cardiovascular disease.
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