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Using a Novel Approach To Treat “Cold” Tumors
New research demonstrates the role of T cells and dendritic cells in patients with "cold" tumors resistant to standard treatment.
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PD-L1: A Therapeutic Target for Malignant Melanomas in Dogs
Scientists have shown that PD-L1 is a potential anti-cancer therapy target for the treatment of metastasized oral malignant melanoma in dogs.
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Large Clinical Trial To Test Polyclonal Antibody Therapeutic for COVID-19
A trial evaluating a new fully-human polyclonal antibody therapeutic targeted to SARS-CoV-2, called SAB-185, has begun enrolling non-hospitalized people with mild or moderate cases of COVID-19.
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New Approach to Gene Therapy Bypasses “Broken” Genes
Researchers have developed a new approach to gene editing using the CRISPR/Cas9 system. The method bypasses disease-causing mutations in a gene, enabling treatment of genetic diseases linked to a single gene, such as cystic fibrosis, certain types of sickle cell anemia, and other rare diseases.
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Fine-Tuning the Bioproduction of Drugs
Researchers have developed technology that allows microbes to produce drugs with feedback control systems, dialing down or amping up protein concentration as needed.
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Study Could Alter Fundamental Ideas on Vaccination and Immune System Function
Research indicates that organ tissues become increasingly immune throughout life, which may begin to alter fundamental ideas regarding the rules of vaccination and the immune system's function within the body.
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Antisense Therapies Developed To Counter Multidrug-Resistant Bacteria
A team from the University of Colorado Boulder has created a drug development platform that can produce effective and highly specific peptide nucleic acid therapies for use against any bacteria within just one week.
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Encouraging Early Results From Clinical Trial of Gene Therapy for Childhood Blindness
According to a clinical trial, a new gene therapy for one of the most common forms of congenital blindness was safe and improved patients’ vision.
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Compound Found in Shrub Targets “Undruggable” Cancer Protein
A Purdue University chemist has discovered a way to synthesize a rare compound found in a shrub native to North America, to fight a previously "undruggable" cancer protein implicated in numerous cancer types.
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Large Trial To Investigate Repurposed Drugs To Treat Mild-to-Moderate COVID-19
The large, randomized, placebo‑controlled Phase 3 clinical trial will explore up to seven drugs approved by US Food and Drug Administration (FDA) for other conditions – an approach called drug repurposing – and test their safety and effectiveness in treating mild-to-moderate COVID-19.
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