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Modified CAR T-Cell Therapy Shows Improved Efficacy in Preclinical Study
Researchers at the University of Freiburg have now been able to prevent the exhaustion caused by CAR-T cell therapy and thus significantly improve the effect of the therapy in a preclinical animal model.
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MicroRNA Could Create Starting Point for New Atherosclerosis Therapy
A specific microRNA molecule has been identified as a promising starting point for the investigation of new therapies for atherosclerosis.
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Reprogrammed Cells Could Tackle Autoimmune Brain Condition
A novel treatment based on CAR-T cells could help tackle encephalitis, a common autoimmune disease, by targeting and eliminating disease-causing cells.
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Dendritic Cell Discovery Holds Key for Developing Novel Vaccines
The finding has major implications for the generation of a strong CD8 T lymphocyte response, a crucial factor in the effectiveness of vaccines against infection.
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Parkinson’s Disease Gene Therapy Shows Promise in Animal Studies
Researchers have developed a gene therapy strategy to selectively manipulate Parkinson's disease-affected circuitry and attenuate the core motor symptoms of Parkinson's disease in rodent and nonhuman primate animals.
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Antibody Targets Tumor-Promoting Molecules Deep Within Cancer Cells
A new approach to cancer treatment uses IgA antibodies to target and destroy tumor-promoting molecules deep within cells and has been described as a more precise, long-lasting and less toxic approach.
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Combining Cell Types Could Lead to Improved Cardiac Cell Therapy
A new study points to an improved method for regenerating heart muscle following a heart attack. Researchers have harnessed a combination of lab-grown cells to regenerate damaged heart muscle.
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AI Identifies Potential Gonorrhea Vaccine Targets
Researchers have used artificial intelligence (AI) to identify promising target proteins with the potential for development into a vaccine against gonorrhea.
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Novel Antibody Can Stop the Spread of Breast Cancer
An enzyme that may help some breast cancers spread can be stopped with an antibody created in Cold Spring Harbor Laboratory. With further development, the antibody might offer an effective drug treatment for those same breast cancers.
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Novel Gene Therapy for Hunter Syndrome
The UK regulatory authorities have approved the first ever trial of a revolutionary gene therapy for young children diagnosed with Hunter syndrome, a devastating rare lysosomal storage disorder.
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