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Errant Editing Enzyme Promotes Tumor Suppressor Loss and Leukemia Propagation
Detection of 'copy editing' by a stem cell enzyme called ADAR1 (active in more than 20 tumor types) may act as a molecular radar for early detection of malignancies, and represent a new therapeutic target.
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Senescent Cell Research Moves into Human Trials
A study of 14 participants with idiopathic pulmonary fibrosis has provided initial evidence that senolytics is a treatment worth pursuing for age-related diseases.
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Race On to Stop New Tick-borne Illness in North America
The ferret has been established as a suitable model for studying how to stop this tick-borne fever-inducing virus.
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Glucagon-producing Cells Forced to Produce Insulin: New Therapeutic Approach for Diabetes?
Following beta cell loss in mice, 1-2% of glucagon-producing α-cells spontaneously engage in insulin production. In this study, this was increased to 5%, providing new insights on cell flexibility and opening up therapeutic approaches for diabetes and other diseases caused by cell death.
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Preventing Cancer Recruiting Our Immune Cells as Double Agents
Cancerous tumors trick myeloid cells, an important part of the immune system, into helping them grow and metastasize, but now there might be a solution.
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'Christmas Berry' Plant Compound Blocks Uveal Melanoma Cell Growth
A compound derived from an ornamental plant in the primrose family is a leading candidate for the treatment of uveal melanoma, the most common eye cancer in adults.
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Bacterial Toxin Offers Chronic Migraine Relief
A growing body of evidence supports the effectiveness of botulinum toxin injections in reducing the frequency of chronic migraine headaches.
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Hollow Microneedles Enable Collection of Dermal Interstitial Fluid
A minimally invasive technique has been developed to extract samples of dermal interstitial fluid - an underutilized biofluid with massive potential in health status monitoring.
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Rare Form of Heart Failure in Pregnancy: Accepted Theory Incorrect
Peripartum cardiomyopathy (PPCM) is a rare form of heart failure that affects women in their last month of pregnancy and up to five months after giving birth. A stem cell-derived model has revealed underlying heart cell defects, which may have important diagnostic and therapeutic implications.
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Stem Cell-derived Neurons Stop Seizures, Improve Cognitive Function
Could cell grafting be the solution to epilepsy? Human induced pluripotent stem cell-derived GABAergic progenitor cells were transplanted into the hippocampus in an animal model of early temporal lobe epilepsy, showing promising results.
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