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Pregnancy-associated Malaria Vaccine Candidate Passes First Test
A vaccine against fatal pregnancy malaria shows promising results in the first tests in humans.
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Microbial Metabolite of Berries Shows Anti-inflammatory Properties
A microbial metabolite, Urolithin A, derived from a compound found in berries and pomegranates, shows anti-inflammatory properties in mice offering potential for inflammatory bowel disease therapies.
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Blood Clot Risk Can Be Increased by Hormone Replacement Therapy
Women who use certain types of hormone replacement therapy (HRT) are at a higher risk of developing potentially life-threatening blood clots, new research has confirmed.
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Protein Prods Cancer-fighting T Cells
A new protein has been created that mimics the action of a key immune regulatory protein, interleukin 2 (IL-2). IL-2 is a potent anticancer drug and an effective treatment for autoimmune disease, but its toxic side effects have limited its clinical usefulness.
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Bone Marrow Transplants Guided by Stem Cell Pathway Insights
Stem cell pathways that lead to differential blood production and imbalances have been revealed in this study which important implications for optimizing bone marrow transplants.
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The Opioid Crisis: 5 Lesson We Should Learn From the AIDS Epidemic
Decades of HIV research demonstrates that an effective biomedical treatment is rarely sufficient to combat an epidemic—suggesting that a social AND biomedical response to the opioid crisis are necessary.
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Errant Editing Enzyme Promotes Tumor Suppressor Loss and Leukemia Propagation
Detection of 'copy editing' by a stem cell enzyme called ADAR1 (active in more than 20 tumor types) may act as a molecular radar for early detection of malignancies, and represent a new therapeutic target.
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Senescent Cell Research Moves into Human Trials
A study of 14 participants with idiopathic pulmonary fibrosis has provided initial evidence that senolytics is a treatment worth pursuing for age-related diseases.
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Race On to Stop New Tick-borne Illness in North America
The ferret has been established as a suitable model for studying how to stop this tick-borne fever-inducing virus.
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Glucagon-producing Cells Forced to Produce Insulin: New Therapeutic Approach for Diabetes?
Following beta cell loss in mice, 1-2% of glucagon-producing α-cells spontaneously engage in insulin production. In this study, this was increased to 5%, providing new insights on cell flexibility and opening up therapeutic approaches for diabetes and other diseases caused by cell death.
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