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Drug Combo Improves Survival of Women with Rare Uterine Cancer
Adding the monoclonal antibody drug trastuzumab - already used to treat certain breast cancers - to the chemotherapy regimen of women with a rare form of uterine cancer lengthens the amount of time their tumors are kept from growing, according to Johns Hopkins Medicine researchers conducting a small Phase II trial of the regimen, testing its safety and value.
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Researchers Receive >$2 Million to Eradicate Common Type of Leukemia
Christoph Rader, PhD, associate professor at the Florida campus of The Scripps Research Institute, has been awarded a $2.875 million, five-year grant from the National Cancer Institute to develop unique antibody-drug conjugates engineered to eradicate one of the most common forms of leukemia, chronic lymphocytic leukemia (CLL).
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Small-Molecule Structure Corrector Fixes Genetic Risk Factor for Alzheimer’s Disease
Using human brain cells, scientists at the Gladstone Institutes discovered the cause of—and a potential solution for—the primary genetic risk factor for Alzheimer’s disease, a gene called apoE4.
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Mystery of Malaria Vaccine Target Solved
The human piece of a malaria infection puzzle has been revealed for the first time, solving a long-standing mystery. A protein displayed on the surface of malaria parasites called "TRAP" is a high-priority vaccine target, but how it interacts with human host cells has remained a puzzle.
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Clues for Improved Influenza Vaccine Design
Influenza vaccines that better target the influenza surface protein called neuraminidase (NA) could offer broad protection against various influenza virus strains and lessen the severity of illness, according to new research published in Cell.
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Allergy Vaccine For Animals Could Lead the Way For Humans
Chronic allergic diseases of dogs and horses can now be treated with an innovative vaccine. The findings obtained in horses and dogs could lead to similar therapeutic vaccines for humans.
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Researchers Reveal How Live Vaccines Enhance the Body's Immune Response
Researchers have discovered a new mechanism by which live vaccines induce immunity. Molecules produced exclusively by live microorganisms are recognized by specialized receptors of the immune system, subsequently triggering a protective immune response.
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Robotics Takes Mass Spec to the Third Dimension
Within the past decade, many advancements have been made in the 3-D market from printing to movies. Now scientists report that by combining a robotic arm and mass spectrometry, they can analyze the surface of irregularly shaped 3-D objects, potentially opening up new branches of forensics and pharmaceutics.
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Flu Virus Discovery Could Lead to Better Prevention and Treatment
Scientists have discovered a new aspect of the flu virus and how it interacts with antibodies in the lungs. This research could lead to a new approach for developing vaccines to prevent the flu, as well as novel treatments for people who are already infected.
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Modified Ligand Helps Activate Cancer-Fighting T Cells
Invariant natural killer T (iNKT) cells are powerful weapons our body's immune systems count on to fight infection and combat diseases like cancer, multiple sclerosis, and lupus. Finding ways to spark these potent cells into action could lead to more effective cancer treatments and vaccines.
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