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New Approach Identifies Important Undiscovered Functions of Proteins

Scientists have developed a new method to discover which surface contacts on proteins are critical for these cellular interactions. The novel approach shows that essential new functions can be uncovered even for well-studied proteins, and has significant implications for therapeutic drug development, which depends heavily on how drugs physically interact with their cellular targets.
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Children With Congenital Zika Virus Infection Face Serious Challenges as They Age

The report from the CDC is the first to describe the health and developmental effects of congenital Zika virus infection in children with microcephaly through 2 years of age.
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Inflammation Causes Chemo Brain

The research could lead to a new practice of identifying inflammatory biomarkers in cancer patients and then treating the inflammation with medications or exercise to improve cognition and other symptoms.
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Single-stranded Origami Technology Drives Drug Delivery Systems and Pharmaceutical Nanofactories Forward

First nanotechnological approach enables the design and replication of complex single-stranded DNA and RNA origami with potential for drug delivery and nanofabrication.
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What Does the Future of Vaccines and Immunotherapy Look Like?

Innovative biomaterials could enhance vaccines against HIV and other infectious diseases and immunotherapies for patients with cancer or dampen responses in autoimmune disorders, allergies and transplanted organ recipients. A review of these efforts was recently released.
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New Computational Strategies Could Help Peptide Therapeutics Development

New computational strategies reported this week might help realize the promise of peptide-based drugs. Peptides are similar to protein molecules, but differ in their smaller size, structure and functions.
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CMC Biologics Announces Development and Manufacturing Agreement with Harpoon Therapeutics

Companies have entered into agreement for the development and manufacturing of three TriTAC molecules for the treatment of cancers.
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Serialization Capabilities Now Operational at Lonza Edinburgh Facility for Liquid-Filled Hard Capsules

Investment in former Capsugel site improves anti-counterfeiting security for Lonza’s global supply chain.
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Tailor-made Protein Fights Several Species of Bacteria

As resistance to existing antibiotics increases, new approaches to serious bacterial infections are needed. Now researchers have investigated one such alternative.
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First Successful Gene Therapy Trial Reported for People with Hemophilia A

Patients with hemophilia A who received a single infusion of an investigational gene therapy showed improved levels of the essential blood clotting protein FVIII, with 11 of 13 achieving normal or near-normal FVIII levels.
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