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Moderna Vaccine Effective Against Virus Variants
Kaiser Permanente research published in The British Medical Journal showed two doses of Moderna COVID-19 vaccine were highly effective against all SARS-CoV-2 variants.
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First Report on Sickle Cell Gene Therapy Long-Term Outcomes
A study of an investigational gene therapy for sickle cell disease has found that a single dose restored blood cells to their normal shape and eliminated the most serious complication of the disease for at least three years in some patients.
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Potential Approach To Alleviate CAR T-Cell Therapy Toxicity
A new approach could help to reduce a serious adverse effect related to chimeric antigen receptor (CAR) T-cell therapy.
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Uncovering the Immune Cells in Play After BCG Vaccination
Researchers have set out to finally uncover exactly how the BCG vaccine works. A better understanding of the vaccination could help to design more effective tuberculosis vaccines.
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Scientists Collaborate To Create Next-Generation Immunotherapy Candidate
Scientists from The Institute of Cancer Research are collaborating with the Cambridge-based immuno-oncology company Crescendo Biologics to develop a potential "next-generation" immunotherapy.
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Vaccine Candidate Could Improve Obesity-Related Disorders
Researchers have developed a peptide vaccine that can alleviate conditions of dyslipidemia, defined as an abnormal level of lipids in the blood, and have proven its efficacy in obese mouse models.
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New Gene-Writing Tool Helps To Develop Advanced Gene Therapies
A team of researchers has published an article in Nature Communications showing the potential of Find Cut-and-Transfer (FiCAT) technology as a state-of-the-art tool for gene writing to develop advanced therapies.
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Intranasal Vaccine Provides Broad-Based Protection Against Respiratory Viruses in Mice
Researchers have found that intranasal vaccination provides broad-based protection against heterologous respiratory viruses in mice, while so-called systemic immunization, which uses an injection to elicit body-wide protection, did not.
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CRISPR-Based Gene Editing Technique Can Insert Entire Genes Into Cells
Researchers have developed a new version of prime editing that can install or swap out gene-sized DNA sequences.
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Memory Cells Work Together To Fight Persistent Viruses
Researchers have found that memory B cells need the help of other memory cells to effectively defend the body against chronic viruses such as HIV, an important finding for vaccine design.
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