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These Immune Players Deserve More Time in the Limelight

News   Sep 21, 2018 | By Heather Buschman, PhD for UC San Diego Health

Cancer Immunotherapy Might Benefit From Previously Overlooked Immune Players

Major Histocompatibility Complex (MHC) molecules display antigens to T cells, immune cells that constantly check for infected or damaged cells. If T cells spot MHC molecules with foreign antigens or mutated self-antigens (such as cancer antigens), they kill the cell before the damage spreads. MHC-II is only displayed by professional immune cells, such as macrophages, and is recognized by CD4+ T cells. MHC-I is displayed on the surface of every cell, and thus any cell with the potential to become cancerous, and is recognized by CD8+ T cells. Credit: UC San Diego Health



Transplanted Brain Stem Cells Survive in Mice Without Anti-rejection Drugs


In experiments in mice, Johns Hopkins Medicine researchers have developed a way to successfully transplant certain protective brain cells without the need for lifelong anti-rejection drugs.


Signals Vital to Immune System's Balancing Act Investigated


A preclinical study shows how the interplay of two interleukin signaling proteins, IL-6 and IL-2, affects the development of Tfh cells. This interplay may either maintain or disrupt the balancing act of the immune system. Thus, the research may help guide future disease treatment.


Diverse Antibodies Thanks to New Loops


Diversity is good, especially when it comes to antibodies. A recent study shows how our immune system's B cells exploit the loop formation process for the purpose of making new kinds of antibodies.



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