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These Immune Players Deserve More Time in the Limelight

News   Sep 21, 2018 | By Heather Buschman, PhD for UC San Diego Health

Cancer Immunotherapy Might Benefit From Previously Overlooked Immune Players

Major Histocompatibility Complex (MHC) molecules display antigens to T cells, immune cells that constantly check for infected or damaged cells. If T cells spot MHC molecules with foreign antigens or mutated self-antigens (such as cancer antigens), they kill the cell before the damage spreads. MHC-II is only displayed by professional immune cells, such as macrophages, and is recognized by CD4+ T cells. MHC-I is displayed on the surface of every cell, and thus any cell with the potential to become cancerous, and is recognized by CD8+ T cells. Credit: UC San Diego Health



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