Fruit Fly Protein Could Help Tackle Disease-Carrying Mosquitos

Published in Nature Communications, the research characterised a protein that is involved in regulating insulin in the fruit fly, which was previously thought to behave in the same way that insulin-like hormones work in humans.

Fruit flies are often used as models for researching many human diseases, particularly neurodegenerative diseases, because the system of releasing insulin and other hormones that stimulate metabolism, cell growth, and cell death are common to humans and animals, including insects.

Scientists at the University of York, however, investigated a protein that is different in the fruit fly compared to its equivalent in humans; they found that insulin-binding in the fruit fly is not the same as it is in humans as was previously thought.

Life-sustaining

Professor Marek Brzozowski, from the University of York’s Department of Biology, said: “It is important that we know exactly how this insulin-dependent life-sustaining system operates because fruit flies are commonly used as models for studying human diseases.

“What is particularly interesting in our new study, is that a protein that regulates hormones in the fruit fly, which is not present in humans, is, however, common to a lot of other insects, and most significantly, to mosquitoes that carry diseases such as malaria, yellow fever, and dengue.

“Now that we know this we can potentially look at inventions that prevents this protein from activating hormones that sustain the lifespan of some of these insects, as well as fine-tune the models we use to study human disease in the fruit fly.”

Genetic modification

There are a number of strands of study for combatting mosquito-borne diseases; one areas looks at drug development to immunise humans against the life-threatening disease and another that is investigating how to genetically modify the insect or disrupt its reproductive abilities to reduce its population size.

Drug develop for some of these diseases, particularly in developing nations, can prove too expensive, however, and so investigating new interventions in the mosquito is a strong area of scientific research. Further study is needed, however, to understand the significance of the mosquito to various ecosystems.

Professor Brzozowski said: “This new finding is exciting because it could open new pathways for drug design for mosquito-borne diseases, as well as take us a step closer to better understanding of some neurological diseases in humans, such as Alzheimer’s, that fruit flies are often studied for.”

This article has been republished from materials provided by the University of York. Note: material may have been edited for length and content. For further information, please contact the cited source.

Reference: Roed, N. K., Viola, C. M., Kristensen, O., Schluckebier, G., Norrman, M., Sajid, W., … Brzozowski, A. M. (2018). Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nature Communications, 9(1), 3860. https://doi.org/10.1038/s41467-018-06192-3