Genmab Licenses DuoBody Platform to Novo Nordisk
News Aug 17, 2015
DuoBody is Genmab's platform for antibodies called bispecific because they bind to two different epitopes, either on the same target or different targets. Genmab reasons that dual-targeting may improve binding specificity and efficacy in inactivating disease targets. According to Genmab, bispecific antibodies generated through DuoBody may improve antibody therapy of cancer, autoimmune, and infectious and central nervous system diseases.
“Today's agreement with Novo Nordisk is an example of how we can leverage access to our unique state-of-the art antibody expertise and collaborations to generate diverse revenue streams in areas beyond cancer,” Genmab CEO Jan van de Winkel, Ph.D., said in a statement.
Under their agreement, Novo Nordisk has agreed to pay Genmab $2 million upfront. After an initial period of exclusivity for the two target combinations, Novo Nordisk has the option to maintain that exclusivity or allow the licenses to become non-exclusive.
Genmab will receive payments tied to potential development, regulatory and sales milestones of approximately $250 million for each exclusive license, or approximately $200 million for each non-exclusive license. Genmab will also be entitled to single-digit royalties on sales of any commercialized products.
Genmab said it expected no material impact on its 2015 financial guidance as a result of its licensing agreement with Novo Nordisk. Genmab has projected 2015 operating income of between DKK 200 million ($29.9 million) and DKK 275 million ($41.1 million), on revenue expected to range between DKK 650 million ($97.1 million) and DKK 725 million ($108.3 million).
Founded in 1999, Copenhagen-based Genmab has one marketed antibody, Arzerra® (ofatumumab) for the treatment of certain chronic lymphocytic leukemia indications, as well as clinical programs that include daratumumab for multiple myeloma and non-Hodgkin's lymphoma. Genmab co-markets Arzerra under a co-development and collaboration agreement with Novartis, as successor in interest to GlaxoSmithKline.
Last month, Novartis, submitted regulatory filings for the drugs maintenance treatment for relapsed chronic lymphocytic leukemia (CLL). with the FDA and European Medicines Agency. The application was based on interim positive results from a Phase III study, PROLONG (OMB112517) which evaluated ofatumumab maintenance therapy versus no further treatment in patients with a complete or partial response after second or third line treatment for CLL. Those results were presented at the 2014 American Society of Hematology Annual Meeting.
Alternative to Antibiotics: Antibody Approach for Treating Multidrug-Resistant Bacterial InfectionsNews
Researchers are developing a promising alternative to antibiotic treatment for infections caused by Klebsiella pneumoniae bacteria resistant to carbapenem antibiotics. The approach uses antibodies to target the K. pneumoniae protective capsule polysaccharide.READ MORE
Combination Drug Trial Launched to Eradicate B-Cell MalignanciesNews
Researchers at University of California San Diego School of Medicine, in collaboration with local biotechnology company Oncternal Therapeutics, have launched a phase Ib/II clinical trial to evaluate the combined effectiveness of a standard of care drug with a novel monoclonal antibody that target B-cell malignancies, which include leukemias and lymphomas.READ MORE
Antigen Study Shows Promise for a Respiratory Syncytial Virus VaccineNews
Medical researchers have been trying to develop a vaccine for respiratory syncytial virus (RSV) for more than 50 years, without success. New findings however, point to a promising route for designing an effective vaccine. Researchers determined the atomic structure of RSV G (major viral surface protein) and identified two sites on it that are targeted by protective antibodies effective against a broad range of RSV strains.READ MORE