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Manufacturing Novel Stem Cell Products To Treat Type 1 Diabetes

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News

Manufacturing Novel Stem Cell Products To Treat Type 1 Diabetes

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The ISLET project, a multi-center collaboration of leading European researchers, aims to develop a manufacturing pipeline for stem cell-based products to treat patients with Type 1 Diabetes. In Type 1 Diabetes a patient’s immune system destroys the beta cells within the islets of Langerhans in the pancreas making a patient depend-ent on life-long delivery of insulin. Based on in-house methods, ISLET aims to deliver a product composed of clusters of insulin-producing beta cells, derived from human pluripotent stem cells, ready to be used in phase 1 clinical trials.

ISLET also aims to advance this product by engineering clusters of hormone-producing cells that not only consist of the insulin-producing beta cells but also other hormone-producing islet cells, thereby engineering a product that is more alike the islets of Langerhans that are found in the pancreas.

Finally, ISLET researchers have the goal of developing innovative solutions to a common bottleneck in stem cell therapy, namely, how to predict the therapeutic capacity of stem cell products.

With hubs at University of Copenhagen, Denmark, and the Helmholtz Diabetes Center, Munich, Germany, the European team of world-leading and complementary expertise such as the lipidomics knowledge, has been carefully hand-picked to move the work smoothly from the lab bench to the clinic and to market the new products.

“I am very proud that prominent researchers from the University of Copenhagen will participate in taking a great leap forward in the field of diabetes research. The ISLET project, coordinated by Professor Henrik Semb, is a strong example of complementary collaboration between world-leading researchers. Furthermore, this demonstrates how long-term dedication to basic research can have a transformative effect. Thus, I hope that future patients will benefit from the development of the clinical stem cell-based transplantation program”, says Ulla Wewer, Dean at The Faculty of Health and Medical Sciences, University of Copenhagen.

The funding is awarded through the Horizon 2020 EU Research and Innovation actions program that also supported the discoveries that laid the foundations for IS-LET, in previous funding rounds.

Type 1 Diabetes is a global health challenge, affecting more than one million children and adolescents worldwide, with close to 129,000 new cases diagnosed each year. Diabetes impacts on quality of life and is a major cause of blindness, kidney failure, heart attacks, stroke and lower limb amputation. The condition is a severe economic burden on healthcare and the labor force.

Professor Henrik Semb, who will lead the study, said: “We are extremely excited and honored that the EU are continuing to support this vital work in driving forward a stem cell therapy for Diabetes. The immensely talented pan-European ISLET team highlights the strength in collaboration between institutions. It is only by working together transparently in this way that we can fulfill the promise that stem cell technology offers to human health globally.”

Prof Dr Sehnaz Karadeniz, IDF Europe Chair, commenting on the project, said:  “IDF Europe is hugely excited to be participating in ISLET, which we believe has the potential to pave the way for a Type 1 Diabetes cure in the future. The funding allocated to this project will have a huge effect on our ability to effectively represent the voice of, and improve the lives of people living with diabetes and connect all relevant stakeholders to ensure that knowledge is shared as broadly and rapidly as possible for maximum impact.”

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