New Approach May Lead to Inhalable Vaccines
News Jan 09, 2015
Researchers at North Carolina State University and the University of North Carolina at Chapel Hill have uncovered a novel approach to creating inhalable vaccines using nanoparticles that shows promise for targeting lung-specific diseases, such as influenza, pneumonia and tuberculosis.
The work, led by Cathy Fromen and Gregory Robbins, members of the DeSimone and Ting labs, reveals that a particle’s surface charge plays a key role in eliciting immune responses in the lung. Using the Particle Replication in Nonwetting Templates (PRINT) technology invented in the DeSimone lab, Fromen and Robbins were able to specifically modify the surface charge of protein-loaded particles while avoiding disruption of other particle features, demonstrating PRINT’s unique ability to modify particle attributes independently from one another.
When delivered through the lung, particles with a positive surface charge were shown to induce antibody responses both locally in the lung and systemically in the body. In contrast, negatively charged particles of the same composition led to weaker, and in some cases undetectable, immune responses, suggesting that particle charge is an important consideration for pulmonary vaccination.
A paper describing the work, “Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization,” was published in the Proceedings of the National Academy of Sciences Dec. 29.
The findings also have broad public health implications for improving the accessibility of vaccines. An inhalable vaccine may eliminate the need for refrigeration, which can not only improve shelf life, but also enable distribution of vaccines to low-resource areas, including many developing countries where there is significant need for better access to vaccines.
Joseph DeSimone is William R. Kenan, Jr. Distinguished Professor of Chemical Engineering at NC State and of Chemistry at UNC, as well as Chancellor’s Eminent Professor of Chemistry at UNC. Jenny Ting is William Rand Kenan Professor of Microbiology and Immunology in UNC’s School of Medicine; she also directs UNC’s Center for Translational Immunology, co-directs the UNC Inflammatory Diseases Institute and is the immunology program leader at the Lineberger Comprehensive Cancer Center.
This work is supported by the National Institute of Allergy and Infectious Diseases-funded Center for Translational Research as well as the Defense Threat Reduction Agency.
H7N9 Influenza Vaccine Clinical Trials CommenceNews
Two new clinical trials testing an experimental vaccine to prevent influenza caused by an H7N9 influenza virus are now enrolling volunteers at sites across the United States. The Phase 2 studies will test different dosages of the inactivated influenza vaccine candidate as well as different vaccination schedules. The studies also will evaluate whether an adjuvant boosts the immune responses of people receiving the vaccine.
Antigen Study Shows Promise for a Respiratory Syncytial Virus VaccineNews
Medical researchers have been trying to develop a vaccine for respiratory syncytial virus (RSV) for more than 50 years, without success. New findings however, point to a promising route for designing an effective vaccine. Researchers determined the atomic structure of RSV G (major viral surface protein) and identified two sites on it that are targeted by protective antibodies effective against a broad range of RSV strains.READ MORE
The Enemy Within: Gut Bacteria Drive Autoimmune DiseaseNews
Bacteria found in the small intestines of mice and humans can travel to other organs and trigger an autoimmune response, according to a new study. The researchers also found that the autoimmune reaction can be suppressed with an antibiotic or vaccine designed to target the bacteria.READ MORE
Comments | 0 ADD COMMENT
World Congress on Clinical And Medical Microbiology
Sep 10 - Sep 11, 2018