Quotient Clinical Signs Cocrystal Agreement with Nuformix
News Oct 19, 2017
Quotient Clinical announced it has signed an agreement with Nuformix Technologies Limited to evaluate the clinical performance of Nuformix’ lead pharmaceutical cocrystal, NXP001, which is based on a currently marketed treatment in the field of oncology supportive care.
Pharmaceutical cocrystals are re-engineered crystalline forms of small molecule drugs, in which a drug and excipient are crystallised together. Resulting cocrystals can offer a number of performance improvements, such as solubility and dissolution of otherwise poorly soluble drugs. Under the terms of the agreement, Quotient will use its Translational Pharmaceutics® platform to develop a formulated oral NXP001 cocrystal product and validate its performance in healthy subjects.
Translational Pharmaceutics integrates formulation development and real-time adaptive GMP manufacturing with clinical research to accelerate the screening and optimization of formulations — for both new chemical entities and life cycle management of existing drugs. In comparison to traditional outsourcing approaches, Translational Pharmaceutics halves drug product development timelines, reduces consumption of drug substance by 85%, and reduces development costs by more than £500,000.
John McDermott, Executive Director, Drug Product Optimisation, Quotient Clinical, said: “We are pleased to announce this new client agreement with Nuformix, whose cocrystal approach further broadens our experience in addressing bioavailability challenges for poorly soluble drugs. This program of work is an excellent illustration of how we can assist our emerging biopharma customers to rapidly validate novel drug delivery technologies and new product concepts.”
Dr Dan Gooding, CEO, Nuformix plc, said: “The appointment of Quotient was not a difficult decision as its Translational Pharmaceutics is perfectly suited to the needs of our NXP001 programme – we were very impressed with Quotient’s overall approach versus alternative options. We look forward to commencing the clinical study and also evaluating the platform’s potential for future Nuformix programmes.”
Worms Exhibit Fear and Respond to Anti-anxiety MedsNews
A team of investigators has uncovered new clues about the mechanisms of fear and anxiety through an unlikely creature: the tiny nematode worm.READ MORE
SMi’s 5th Annual Molecular Diagnostics Conference 2018 Agenda ReleasedNews
SMi proudly presents its 5th annual conference on Molecular Diagnostics, taking place at the Holiday Inn Kensington Forum, London, UK on 9th and 10th July 2018, with a half-day post-conference workshops on 11th July 2018.READ MORE
Harvard Bioengineers’ Biomaterial-Based Cancer Immunotherapies to be Developed by NovartisNews
The Wyss Institute for Biologically Inspired Engineering at Harvard University and the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) announced today that Novartis will have access to commercially develop their therapeutic, biomaterial-based, cancer vaccine technology that promotes anti-cancer immunity.READ MORE
Comments | 0 ADD COMMENT
Microbiome Futures: A Global Translational Roadmap
May 23 - May 23, 2018
International Conference on Neuroimmunology, Neurological disorders and Neurogenetics
Sep 26 - Sep 27, 2018