Shingles Vaccine Reduces Dementia Risk by 20%

Vaccination to prevent shingles also reduces the risk of developing dementia in later life, according to a research paper published recently in Nature. This conclusion is based on the analysis of data collected in connection with the introduction of a shingles immunization program launched in Wales in 2013. Economists with their special expertise in statistical analyses have made a significant contribution to the corresponding study. "We were able to apply our capabilities in statistics to medical data, thus forging a bridge between these two fields," said Dr. Markus Eyting of Johannes Gutenberg University Mainz (JGU), lead author of the study. Together with co-lead author Dr. Min Xie, a postdoctoral researcher at the Heidelberg Institute of Global Health, he demonstrated that the shingles vaccination was associated with a 20 percent reduction in the probability of a new dementia diagnosis over a period of seven years. As noted in the article, "A natural experiment on the effect of herpes zoster vaccination on dementia," this could raise various new possibilities for dementia prevention.

Electronic health records for Wales supply basis for statistical analysis

Dr. Min Xie identified the groundwork of what would represent a "natural experiment" created by the introduction of a herpes zoster vaccination program in Wales about two years ago. In the program, the eligibility to receive the vaccine was determined by an individual's exact date of birth. Those born before 2 September 1933 were automatically ineligible for life, while those born on or after 2 September 1933 were entitled to receive the vaccine. "We can speak of a natural experiment in this context because this setting gives us the opportunity to compare individuals who had just turned 80 with those who had not quite reached 80 years of age," Eyting explained. Because the individuals in the study cohort were only a few weeks apart in age, the researchers could assume that vaccination was the only factor that set the groups apart. "We then looked at the risk of developing dementia over the next seven years," Eyting continued.

One of the main goals of the analysis was to identify a potential causal effect rather than just a correlation. In other words, the researchers were looking for a causal relationship between the shingles vaccine and the risk of developing dementia, not just a random connection between the two factors. In economics, threshold values and target dates – in this case, the individuals' birthdays – are often employed to test for causal effects using regression discontinuity designs. "This method is widely used in economics but has not yet been adequately recognized as a tool for clinical research," Eyting added. In his view, regression discontinuity analyses offer many opportunities for evaluating the effectiveness of public health measures.

Reference: Eyting M, Xie M, Michalik F, Heß S, Chung S, Geldsetzer P. A natural experiment on the effect of herpes zoster vaccination on dementia. Nature. 2025. doi: 10.1038/s41586-025-08800-x

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.