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Using Machine Learning To Create Better Gene Therapies

News   Feb 12, 2021 | Origainl story from the Wyss Institute

 
Using Machine Learning To Create Better Gene Therapies

In their machine learning-based capsid diversification strategy, the team focused on a 28 amino acid peptide within a segment of the AAV2 VP3 capsid protein that exposes the AAV capsid to neutralizing antibodies produced by individuals and thus can be the cause of an immune response against the virus. More purple colored portions of this peptide are buried deeper in the capsid, while yellow parts are exposed on the virus' surface. Credit: Wyss Institute at Harvard University (original by Drew Bryant).

 
 
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