Zika Immunity Molecule Found
A molecule naturally produced by the immune system protects mice and monkeys against Zika virus infection, an international team of researchers has found. Administering the molecule, called 25-hydroxycholesterol or 25HC, to pregnant mice reduced Zika virus infection in the fetal brain and protected against Zika-induced microcephaly. The work was supported in part by the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health.
Previous experiments suggested that 25HC has broad antiviral activity. In the new study, researchers led by Genhong Cheng, Ph.D., of the University of California, Los Angeles, investigated whether 25HC has a protective effect against Zika virus, for which there is no licensed antiviral drug or vaccine. Their initial cell culture experiments indicated that 25HC can block Zika and related viruses, including dengue and yellow fever viruses, from entering cells.
The researchers next established that 25HC is protective in mouse and monkey models of Zika virus infection. For example, mice given 25HC before being infected with Zika virus had significantly lower blood levels of the virus than mice given a placebo. 25HC-treated mice were more likely to survive Zika infection, and the surviving mice had no clinical symptoms. Monkeys given 25HC also had reduced levels of Zika virus in blood and urine and did not develop a fever in response to infection.
To determine whether 25HC could protect against Zika-induced microcephaly, the researchers gave pregnant mice 25HC or placebo before and for five days after their embryos were infected with Zika virus. Treatment with 25HC significantly decreased levels of Zika virus in fetal mouse brain tissue and greatly reduced the occurrence and severity of developmental defects, including small fetal brain size. The researchers did not observe any adverse effects on pregnancy or birth related to 25HC treatment.
The authors conclude that 25HC shows promise as a natural agent that can combat a broad array of viruses, including Zika virus. Additional preclinical research is needed before investigating whether 25HC can safely protect humans against Zika virus infection and associated birth defects.
This article has been republished from materials provided by National Institute of Allergy and Infectious Diseases, NIH. Note: material may have been edited for length and content. For further information, please contact the cited source.
Li, C., Deng, Y., Wang, S., Ma, F., Aliyari, R., Huang, X., Zhang, N., Watanabe, M., Dong, H., Liu, P., Li, X., Ye, Q., Tian, M., Hong, S., Fan, J., Zhao, H., Li, L., Vishlaghi, N., Buth, J., Au, C., Liu, Y., Lu, N., Du, P., Qin, F., Zhang, B., Gong, D., Dai, X., Sun, R., Novitch, B., Xu, Z., Qin, C. and Cheng, G. (2017). 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model.
Innate Reaction of Hematopoietic Stem Cells to Severe InfectionsNews
Researchers at the University of Zurich have shown for the first time that hematopoietic stem cells detect infectious agents themselves and begin to divide, without signals from growth factors.READ MORE
Cow Antibodies Yield Important Clues For Developing A Broadly Effective AIDS VaccineNews
The unexpected animal model is providing clues for important questions at a moment when new energy has infused HIV vaccine research.READ MORE
CRISPR Reveals New Targets for Promising Cancer DrugsNews
Novel screening method identifies new drug targets that could potentially enhance the effectiveness of PD-1 checkpoint inhibitors, a promising new class of cancer immunotherapy.READ MORE
Comments | 0 ADD COMMENT
EMBL Course: Transgenic Animals - Micromanipulation Techniques
Apr 10 - Apr 11, 2018
EMBO Practical Course: Extracellular Vesicles: From Biology to Biomedical Applications
Apr 09 - Apr 13, 2018
EMBO | EMBL Symposium: Tissue Self-Organisation: Challenging the Systems
Mar 11 - Mar 14, 2018