A Rapid and Effective Tool for Monitoring Monoclonal Antibody Production
Poster Aug 13, 2014
B. Bhullar, Ph.D., Carlina Hui, B.Sc., M. Hariharan, M.Sc., J. Hewitt, B.Sc , and N. Vats, Ph.D.
IVD manufacturers must establish QC systems to assure that the product received is suitable for use. As an alternative to laborious time consuming conventional methods such as ELISA or dot immunobinding, we examined the effectiveness and utility of rapid point-of-use immuoanalytical tools created with MedMira's MiriadTM RVF Toolkit to quickly assess the suitability of hybridoma bioreactor supernatants.
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluationPoster
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE
MHV68 Infection in a Novel rag2 F62L/F62L Mouse Model Based on a Patient with CID-G/AI PhenotypePoster
MHV-68 infection in our rag2 mouse model induced increased antibody responses to virus and self and inflammatory disease in end organs. Major mechanism of inflammatory infiltrates and autoantibody generation is yet to be determinedREAD MORE