Alfa Chemistry Expands Pharmaceutical Product Portfolio: Introducing PROTAC Building Blocks, Nucleosides, Intermediates and APIs

Alfa Chemistry now has an extensive range of products within the pharmaceutical field, including PROTAC building blocks, nucleosides, intermediates and Active Pharmaceutical Ingredients (APIs).

Proteolysis-targeting chimera (PROTAC) is a revolution in protein degradation. PROTACs take over the ubiquitin-proteasome system to degrade pathogenic proteins. They’re complex molecules made up of an E3 ligase ligand, a protein-binding ligand (also called the warhead), and a linker that links those two functional components. Alfa Chemistry’s library includes many different PROTAC scaffolds needed to make these advanced bi-functional molecules. These include E3 ligase ligands such as CRBN and VHL, and linkers which act as a mediator between target proteins and ligases to broaden the therapeutic options (especially in the treatment of cancer and neurodegenerative diseases).

Nucleosides, the building blocks of nucleic acids, aren’t only simple building blocks for RNA and DNA. In medical applications, they’re used in cancer therapies and viral infection drugs. Alfa Chemistry makes this possible by providing pure and highly diverse nucleosides with modified versions used in the development of oligonucleotide therapeutics. These nucleosides are not just helpful in generating genes but also for the production of anticancer and antiviral drugs that could make medicines that work and are well tolerated in all manner of ailments.

Pharmaceutical intermediates are the building blocks of APIs and the building blocks of therapeutic compounds. Alfa Chemistry provides a wide variety of these intermediates which meet strict quality and safety requirements required for the drug development process. These intermediates (ammonium acids, organic acids, esters and heterocyclic compounds) allow us to innovate in drug synthesis, which in turn leads to more effective and precise drugs.

The real essence of any drug are its APIs, the chemicals that have the therapeutic action. Alfa Chemistry’s APIs are manufactured to the highest standards of quality and performance. Not only are these APIs key to drug production but also help make treatments effective because they ensure consistency and dependability in their efficacy.

Besides products, Alfa Chemistry is also very focused on service diversification by providing customized synthesis and research assistance to its global clients. This includes medicinal and synthetic chemistry services, analytical and bioorganic chemistry services, and total pharmaceutical preparation services. Dedicated efforts like these are the reason why researchers and developers trust Alfa Chemistry as a reliable partner to help them promote new drug discoveries and innovation.