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AMSBIO Highlights Groundbreaking 2023 Life Science Research

Microscopic image of engineered human skin.
Credit: AMSBIO.
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In an informative new blog post - AMSBIO reflects on a selection of the groundbreaking life science and biomedical research undertaken by its customers during 2023. From deciphering the intricacies of cancer progression mechanisms to revolutionising wound care, AMSBIO is delighted to have played a supporting role in these scientific endeavours.

Discover an exciting collaboration led by Dr. Ashley M. Laughney from Weill Cornell Medicine and Dr. Samuel F. Bakhoum from Memorial Sloan Kettering Cancer Center where they investigated the intricate mechanisms through which chromosomal instability drives cancer metastasis. Their research revealed the complex interplay between chromosomal instability and the immune system, revealing the chronic activation of the cGAS–STING pathway and its role in creating a pro-metastatic tumour microenvironment. Using CAG-Luciferase lentiviral particles from AMSBIO the researchers developed in mouse models of breast cancer, enabling them to monitor the metastatic progression through bioluminescence. This pioneering research marks a significant stride toward advancing cancer therapies, offering valuable insights into potential therapeutic interventions for melanoma, breast, and colorectal cancers.

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See the visualisations of Professor Peter K. Sorger’s research group at Harvard Medical School, who have shown the efficacy of spatial biology in discovering visual cancer biomarkers compared to traditional histology techniques. The study utilized the 'Orion' platform, which facilitates the collection of H&E and high-plex immunofluorescence images for cancer diagnosis. Professor Sorger’s team used FFPE tonsil and lung adenocarcinoma tissue from AMSBIO’s vast biorepository during their optimisation procedures. Using a colorectal cancer cohort, their study demonstrated that combining models of immune infiltration and tumour-intrinsic features through multimodal tissue imaging achieves significant discrimination in predicting progression-free survival. This research underscores the platform's potential for advancing clinical research and cancer diagnosis.

Explore the work at Columbia University Irving Medical Center, where Dr. Hasan Erbil Abaci's team used Hyaluronan Binding Protein from AMSBIO in their groundbreaking study on engineered wearable edgeless skin constructs (WESCs). Traditional skin constructs are flat and struggle to cover intricate areas like hands after injuries. The WESCs from the Columbia University team are designed to replicate the enclosed 3D geometry of human skin, to overcome this limitation. With improved biomechanical properties, these constructs have the potential to revolutionise wound care for complex body sites, presenting a significant advancement in the field.