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Engineering Recombinant Antibodies into New Formats

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Absolute Antibody, an provider of recombinant antibody products and services, has announced a partnership with the Recombinant Antibody Network (RAN), a consortium of three expert centers at the University of Chicago, University of Toronto, and UC San Francisco (UCSF) with a common goal to generate recombinant antibodies at a proteome-wide scale. Under the new partnership, select recombinant antibodies made by the Recombinant Antibody Network will be engineered into new formats and made available to a wider scientific audience via Absolute Antibody’s online reagents catalog.

The sequences and validation data for more than 200 antibodies directed to intracellular targets generated by the Recombinant Antibody Network have been licensed to Absolute Antibody by the University of Chicago’s Polsky Center for Entrepreneurship and Innovation on behalf of the RAN. The collection includes antibodies against key transcription- and translation-regulating proteins, such as chromobox and bromodomain proteins, and other targets involved in important areas of biology research, including chromatin biology and infectious disease control. Absolute Antibody will use the sequences and data to recombinantly produce the antibodies in a variety of engineered formats designed to enable new experimental possibilities.

The engineered recombinant antibodies will be added to Absolute Antibody’s online reagents catalog, where researchers worldwide can easily access them. They will be offered in different species to readily enable co-labeling studies and in antibody fragment formats to reduce background in immunoprecipitation studies. All the antibodies are defined at the amino acid level to ensure batch-to-batch reproducibility, high purity and low endotoxin levels.