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Enterprise Therapeutics Awarded Up to $7M From Cystic Fibrosis Foundation

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Enterprise Therapeutics, a biopharmaceutical company involved in the discovery and development of novel therapies for patients suffering with respiratory disease, has announced it has been awarded up to $7M funding under the Therapeutics Development Award programme from the Cystic Fibrosis Foundation. The milestone-related funding will support clinical development up to the end of Phase 2 for ETD002 – a first-in-class TMEM16A potentiator that has the potential to treat patients with cystic fibrosis (CF), independent of their cystic fibrosis transmembrane conductance regulator (CFTR) mutation type.

Enterprise Therapeutics is developing novel disease-modifying therapies which target underlying mechanisms of mucus congestion, enhancing the clearance of mucus from the airways, thereby restoring lung function and to reduce morbidity and mortality in CF.  The company’s ETD002 programme is targeting the calcium-activated chloride ion channel TMEM16A. By enhancing the activity of TMEM16A, there is increased anion and fluid flow into the airways, thinning the mucus and increasing its clearance from the airways.

Dr John Ford, CEO, Enterprise Therapeutics, said: “We are delighted to receive such a significant award from the CF Foundation. This funding will enable critical clinical research to be undertaken on our novel TMEM16A programme and highlights the potential of chloride channel modulation via alternative channels to deliver innovative and effective treatments for all CF patients.”