TOYOPEARL® Sulfate-650F Process Chromatography Resin

Tosoh Bioscience LLC, a provider of chromatographic resins for the purification of biopharmaceutical drugs in commercial manufacturing processes, today announced the introduction of TOYOPEARL Sulfate-650F, a strong cation exchange resin that exhibits high salt tolerance. TOYOPEARL Sulfate-650F resin is now available for sale in the Americas from Tosoh Bioscience LLC.

TOYOPEARL Sulfate-650F resin allows for lowered operating costs by offering higher dynamic binding capacities for IgG. This resin can easily achieve a dynamic binding capacity of >120 g/L of monoclonal antibody (mAb) and exhibits excellent pressure-flow properties at 30 cm ID up to 500 cm/hr (0.2 MPa). TOYOPEARL Sulfate-650F is ideal for applications performed in physiological conditions or for postprotein A removal of aggregates.

“We are very pleased to introduce this exceptional addition to our process media product line,” says Dr. Phu Duong, Product Manager II, Process Media. “TOYOPEARL Sulfate-650F resin provides the strongest capture of monoclonal antibody aggregates over a wide pH range without losing its binding capacity for mAb, resulting in higher resolution between monomer and aggregates.”