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TriLink BioTechnologies® Solidifies IP Position With Awarded Patents for CleanCap® Capping Technology in China and Canada

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TriLink BioTechnologies (TriLink®), a Maravai LifeSciences company (NASDAQ: MRVI) has been granted patents by the China National Intellectual Property Administration (CNIPA) and the Canadian Intellectual Property Office (CIPO). Patent numbers ZL 2023 1 0734863.0 and CA 2999274 are related to TriLink’s CleanCap® technology for the co-transcriptional capping of mRNAs – a critical component of the production of synthetic mRNA as drug developers and researchers strive to maximize the impact of mRNA-based therapeutics and vaccines.

“TriLink’s CleanCap technology is helping to bring life-saving therapeutics and vaccines to market faster”

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These new issuances in China and Canada re-enforce the global strength and protection of TriLink’s intellectual property, adding new jurisdictions to the list of other major world markets in which CleanCap® technology is already patented, including the United States, European Union, Australia, Japan, Korea, and Hong Kong.

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“mRNA technology continues to prove its value as a breakthrough modality for innovative medicines,” explained Drew Burch, President of Nucleic Acid Production at TriLink. “Obtaining patents in these key markets demonstrates the value of the CleanCap® technology and its use in mRNA in drugs for clinical studies and commercialization worldwide – the promise and pace of this industry is unmatched.”

The technology encompassed by the patents facilitates the production of mRNAs containing the major natural cap structures found in humans, a significant improvement over legacy capping methods such as enzymatic and ARCA. CleanCap® technology has been used in commercially approved COVID-19 mRNA and saRNA vaccines.

“TriLink’s CleanCap technology is helping to bring life-saving therapeutics and vaccines to market faster,” added Kurt Oreshack, Executive Vice President & General Counsel, Maravai LifeSciences. “These additional jurisdictions fortify the validity and strength of our global intellectual property.”

Last May, TriLink launched its most robust analog to date: CleanCap® M6. The technology’s single-pot reaction capabilities are expected to shrink manufacturing times, reduce manufacturing costs by 20-40%*, increase protein expression by >30%, and increase mRNA yields with a purity profile of >95%. Its impressive performance and positive impact on the industry have earned CleanCap® M6 analog two industry innovation recognitions with Pharma Manufacturing and The Medicine Maker.