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Alliance™ iS Bio HPLC System
With the introduction of the Alliance™ iS Bio HPLC System comes intuitive simplicity for biopharma, Your biopharmaceutical quality control (QC) lab faces the relentless demand to do more with less. Trying to reduce common errors to improve efficiency and productivity, while managing the growing levels of complexity in biological samples, makes the need for intuitive simplicity in your lab more important than ever. With the Alliance iS Bio HPLC System, featuring MaxPeak High Performance Surfaces (HPS) Technology, you can reduce unwanted interactions between your samples and the HPLC system, rroduce faster and more reproducible results with improved data integrity, reduce human errors up to 40% (Based on Waters market research in 2022, surveying fifty-six global pharma QC labs running over twenty-five systems) through intuitive system intelligence, reduce training requirements with intuitive touchscreen operation and guided workflows. With performance features developed specifically for the biopharma laboratory, the Alliance iS Bio HPLC System will quickly become your favorite ally.
Non-specific adsorption (NSA) of metal-sensitive compounds, such as oligonucleotides and phosphopeptides, is an unpredictable challenge leading to long column passivation times, chromatography with large relative standard deviations (RSDs), and broad peaks that can be challenging to detect.
The Alliance iS Bio HPLC System is a step-change above traditional biocompatible systems. With corrosion-resistant construction materials to maximize system robustness under high salt extremes, and MaxPeak HPS Technology to minimize non-specific adsorption of metal-sensitive analytes without complicated mobile phases or laborious methods, you experience faster, more reproducible, and accurate data integration; shorter time from sample to result by eliminating the need for system conditioning; and the ability to meet compliance standards with higher quality data.
Size-exclusion chromatography (SEC) is a powerful separations technique for monoclonal antibody (mAb) characterization and quality control. With the Alliance iS Bio HPLC System, you can confidently run your legacy mAb separations while meeting system suitability criteria for compendial methods and improving resolution due to lower system dispersion. In addition, acidic peptides and phosphopeptides can be very challenging to separate using conventional HPLC systems. The Alliance iS Bio HPLC System featuring MaxPeak HPS Technology is designed to minimize unwanted protein interactions with the system while improving recovery, retention time consistency, and peak shapes. With the Alliance iS Bio HPLC System, you can reduce analysis times and save resources by scaling your peptide methods to 2.5 µm from 5 µm chemistries.
Your systems need to support both legacy and new methods that can be operated repeatably anywhere in the world while meeting regulatory requirements. These requirements can place a large burden on your analysts, but failing to perform necessary tasks could put your organization at risk. One of the advanced tools available with the Alliance iS Bio HPLC System is the Intelligent Method Translator App (iMTA), which will assist you with method migration from other systems, automatically and compliantly. Additionally, when coupled with Empower Software Solutions and eConnect HPLC Columns, analysts gain access to new features. Method Matching warns users when attempting to use an unsupported method on the system. Empower System Audit Trail automatically captures installation of and modifications to the system and system software for added traceability. Column history tracking is automated. waters_connect System Monitoring allows for real-time fleet management.