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ioMicroglia™ – Consistent iPSC-Derived Microglia, Ready in 10 Days!

ioMicroglia™ – Consistent iPSC-Derived Microglia, Ready in 10 Days!

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ioMicroglia are cryopreserved human iPSC-derived microglia powered by bit.bio’s opti-ox™ precision reprogramming technology, built so scientists no longer have to battle with long differentiation protocols that produce inconsistent cell populations.

In just 10 days post-revival, ioMicroglia show:
  • A typical ramified morphology
  • Consistent and defined cell populations
  • Expression of key phenotypic markers (TMEM119, P2RY12, IBA1, TREM2, CX3CR1, CD11b, CD45, and CD14)
  • A transcriptomic signature with high equivalence to primary adult and foetal microglia
  • Key human microglia functions with lot-to-lot consistency, including mediating an inflammatory response, disposal of unwanted materials, and carrying out immune surveillance. 
  • Co-culture compatibility with bit.bio ioGlutamatergic Neurons, to gain insights into complex intercellular interactions.

  • ioMicroglia are available now. Request a quote today. 

    Product Specifications
    Marker expression TMEM119, P2RY12, IBA1
    Vial size 1.5 million viable cells
    Shipping format Cryopreserved
    Viability >80%
    Seeding density 37,000-39,500 cells/cm2
    Seeding compatibility 6, 12, 24, 96 and 384 well plates
    Validated functions Phagocytosis, cytokine secretion, co-cultures with neurons
    Price Available on request
    About bit.bio
    bit.bio is an award-winning human synthetic biology company based in Cambridge, UK. Our cell identity coding platform has the ability to create any human cell type and to manufacture it at scale with precision and consistency. Having access to human cells has the potential to unlock a new generation of medicine: it will enable research and drug discovery to move on from inappropriate models and work with the cells that actually are affected by human disease and form the basis for a new generation of cell and tissue therapies. It will enable us to realise our vision: biomedical innovation and a new generation of cures through precision reprogrammed human cells. The cell identity coding platform consists of three core parts: our discovery platform which identifies the precise code that defines cell fate; our precision cellular reprogramming technology - opti-ox - that deterministically reprograms stem cells into any cell type; and our world leading expertise in stem cell reprogramming, manufacturing and clinical translation. Using our platform, we have already launched multiple wild type and disease model cells under our ioCells™ brand for research and drug discovery. The platform also means we can offer custom partnership capabilities. And we are currently building our own, in-house cell therapy pipeline using our platform.