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ioMicroglia™ – Consistent iPSC-Derived Microglia, Ready in 10 Days!

ioMicroglia™ – Consistent iPSC-Derived Microglia, Ready in 10 Days!

ioMicroglia are cryopreserved human iPSC-derived microglia powered by bit.bio’s opti-ox™ precision reprogramming technology, built so scientists no longer have to battle with long differentiation protocols that produce inconsistent cell populations.

In just 10 days post-revival, ioMicroglia show:
  • A typical ramified morphology
  • Consistent and defined cell populations
  • Expression of key phenotypic markers (TMEM119, P2RY12, IBA1, TREM2, CX3CR1, CD11b, CD45, and CD14)
  • A transcriptomic signature with high equivalence to primary adult and foetal microglia
  • Key human microglia functions with lot-to-lot consistency, including mediating an inflammatory response, disposal of unwanted materials, and carrying out immune surveillance. 
  • Co-culture compatibility with bit.bio ioGlutamatergic Neurons, to gain insights into complex intercellular interactions.

  • ioMicroglia are available now. Request a quote today. 

    Product Specifications
    Marker expression TMEM119, P2RY12, IBA1
    Vial size 1.5 million viable cells
    Shipping format Cryopreserved
    Viability >80%
    Seeding density 37,000-39,500 cells/cm2
    Seeding compatibility 6, 12, 24, 96 and 384 well plates
    Validated functions Phagocytosis, cytokine secretion, co-cultures with neurons
    Price Available on request
    About bit.bio
    bit.bio is a synthetic biology company providing human cells for research, drug discovery and cell therapy.