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ioSensory Neurons: Human iPSC-Derived Neurons for Reliable Pain Research

ioSensory Neurons: Human iPSC-Derived Neurons for Reliable Pain Research

One of the biggest challenges in pain research is the lack of a physiologically relevant in vitro cell models with consistent nociceptor marker expression and functionality. 

ioSensory Neurons are built to address this challenge. They are a highly pure, easy to use and functional human iPSC-derived nociceptor model. As the cells are precision reprogrammed with opti-ox™ technology, ioSensory Neurons have consistency built-in and always express the same key markers regardless of lot or vial. Such consistency, combined with an unprecedented over 99% purity, a validated functional nociceptor phenotype and a simple protocol will help chronic pain researchers to improve the reliability and reproducibility of their experiments.

Within 7 days post-revival, ioSensory Neurons form a highly pure sensory neuronal population with a defined nociceptor identity, characterised by the expression of the pan-sensory neuron markers, PRPH, BRN3A, ISL1 and TUBB3, and key markers of nociceptors, NTRK1 and TRPV1. These cells also display spontaneous activity and show a functional nociceptor phenotype, as demonstrated by responsiveness to noxious stimuli against TRPV1, TRPM3, and TRPM8.

Don’t settle for non-human in vitro models or long, complex iPSC differentiation protocols that lead to inconsistent results. Start running reliable nociception assays with ioSensory Neurons today.

ioSensory Neurons are now available under an early access program. Fill out the form to speak to an expert about ioSensory Neurons. 

Product Specifications
Starting material Human iPSC line
Donor Caucasian adult male (skin fibroblast)
Karyotype Normal (46, XY)
Differentiation method opti-ox cellular reprogramming
Format Cryopreserved cells
Quality control terility, protein expression (ICC) and gene expression (RT-qPCR)
Vial size >2 x 10⁶ viable cells
Seeding compatibility 6, 12, 24, 96 and 384 well plates
Recommended seeding density 60,000 cells/cm²
Product use Research use only
About bit.bio
bit.bio is an award-winning human synthetic biology company whose mission is to code cells for novel cures. They have developed an end-to-end platform for the creation of any human cell type. With their cutting-edge and patent-protected opti-ox<sup>™</sup> precision cell programing technology, bit.bio can deterministically program human induced pluripotent stem cells (iPSCs) into a chosen cell identity with unprecedented biological consistency at an industrial scale and approximately 10 times faster than conventional methods. Their platform has the potential to unlock a new generation of medicines.
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