XS Technologies® - The Microbial Expression Systems For Today’s Therapeutics
To deliver new therapies to patients, novel molecules must be produced quickly and at scale using robust systems and processes. In addition, regulatory compliance is critical to enable migration into the clinical setting and ultimately to the market. For more than 30 years, Lonza has pioneered enhanced microbial expression systems. These have been implemented in over 130 projects for the expression of a wide range of proteins, including enzymes, cytokines, fusion proteins and growth factors, in addition to next generation biologics such as scFvs and antibody mimetics. Leverage the power of the XS Technologies® microbial platform (including Pichia and E. coli expression systems) in your own lab with a Lonza in Your Lab® license. Or, leave strain and process development in Lonza’s hands with our microbial CDMO services.
The success of any production process depends on numerous factors. In addition to the platform used, manufacturing must harness and optimize complex interactions. For example, balanced growth and production phases can maximize yield. However, that yield may exact a tradeoff with the accumulation of toxic metabolites, which together with host proteins, can impact downstream applications. Alignment is required to ensure performance and prevent unwanted post-translational modifications. The XS Technologies® platform offers a toolbox of system components that enable effective screening of different options for optimal expression of your product. This enables you to establish productive, robust, scalable and efficient cGMP processes more quickly and easily.
One toolbox of expression system components enables you to screen and make impactful choices:
• Host strains - Select the best strain that meets your product specifications
• Promoters - Variety of promoters to choose from that aligns with your process specifications
• Helper factors - Access to helper factors that can influence recombinant protein production
• Signal sequences - A number of proprietary signal peptides that can help promote secretion of products and improve product quality
• Feed regime - Specially designed Lonza feed regime to achieve short fermentation times, high yields, low biomass or a balance of all
• Know-how - Access to protocols, tools and analytical methods developed by Lonza over decades of experience delivering customer projects
XS Technologies® are the microbial expression systems for today’s therapeutics. While achieving yields of up to 20 g/L for simple proteins and up to 12 g/L for more complex proteins, they merge simplicity and scalability. XS Technologies® Expression Systems can help accommodate industry trends, eliminate production bottlenecks, align downstream processing and drive breakthroughs into the clinic.
