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Biomarkers – Multimedia

Video

Microfluidic Systems for Biomarker Analysis and Cancer Diagnosis

In this talk, Martin Gijs discusses a novel magnetic surface coverage assay and a microfluidic tissue processor with applications in cancer diagnostics.
A multianalyte algorithm PCR-based blood test outperforms single analyte ELISA-based blood tests for neuroendocrine tumor detection content piece image
Poster

A multianalyte algorithm PCR-based blood test outperforms single analyte ELISA-based blood tests for neuroendocrine tumor detection

In a prospective study, in age-/sex- and ethnicity-matched patients and controls (n=82), a 51 panel multigene blood transcript test (NETest) was identified to be significantly more sensitive and accurate (>93%) than any single analyte assay (Chromogranin A, Pancreastatin or Neurokinin A) for neuroendocrine tumor detection.
App Note / Case Study

Automating ELISAs on Tecan’s Freedom EVO® using Optimiser™ technology from Siloam Biosciences

One of the challenges in life sciences research today is to discover methods for running key assays more quickly, more reliably and using lower volumes of reagents and sample, but still with improved sensitivity. One area where this particularly holds true is for traditional enzyme-linked immunosorbent assays (ELISAs), whose application provides a useful measurement of antigens, including cytokines and a host of other biomarkers.
Development and optimization of a procedure for extracting proteins from fixed archival tissues and assessment of its potential for biomarker discovery in human and veterinary medicine content piece image
Poster

Development and optimization of a procedure for extracting proteins from fixed archival tissues and assessment of its potential for biomarker discovery in human and veterinary medicine

Fixed tissue repositories are an ideal information mine for biomarker discovery, with their vast collections of diseased tissues and associated clinical records describing diagnosis, prognosis, therapy, and outcome.
Does the increase of exosomal microRNAs reflect an activated immune system in melanoma? content piece image
Poster

Does the increase of exosomal microRNAs reflect an activated immune system in melanoma?

Cutaneous malignant melanoma is a form of skin cancer that accounts for 65% of skin cancer-related deaths. The incidence increases continuously, and while early detection leads to nearly 100% survival rates, the mortality raises to greater than 80% for patients with advanced disease.
Novel Nucleosomics Serum Biomarkers for the Detection of Colorectal Cancer content piece image
Poster

Novel Nucleosomics Serum Biomarkers for the Detection of Colorectal Cancer

As colorectal cancers are often detected at late tumor stages when prognosis of the patients is poor, powerful blood-based biomarkers are needed for earlier detection. In recent years it has become clear that epigenetic changes to chromatin and its constituent nucleosomes are associated with carcinogenesis and elevated levels of nucleosomes are present in the blood of cancer patients.
Over-representation of Proteins Identified as Disease Biomarkers and their Relation to Post-Mortem Events content piece image
Poster

Over-representation of Proteins Identified as Disease Biomarkers and their Relation to Post-Mortem Events

Tissue sampling is a major traumatic event that can have drastic effects within a very short timeframe at the molecular level resulting in loss of sample quality due to post sampling changes. It has recently been reported that the same proteins, regardless of tissue origin or species, are often found expressed differentially in various disease states, bringing into question the significance of these proteins as biomarkers.
Video

The Isolation and Characterization of Brain Metastasis – Competent Breast Cancer CTCs

Dario Marchetti, Professor/Director, Baylor College of Medicine, speaking at CellTech 2013.
Metal Polymers, A Glue to Immobilise Proteins Onto Synthetic Surfaces content piece image
Poster

Metal Polymers, A Glue to Immobilise Proteins Onto Synthetic Surfaces

The main objective of this work was to develop a surface chemistry which maintains protein function and orientation per unit surface area, regardless of the surface used.
App Note / Case Study

PSVue®: Novel small molecule probes for fluorescent imaging of apoptosis and bacterial infections in vitro and in vivo

PSVue® offers a robust alternative to probes currently used by researchers to detect early-to-mid stage apoptosis, as well as bacterial infections.
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