Biomarkers – News and Features

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Researchers Identify Biomarkers for Liver Cancer Immunotherapy
Researchers link NBR1 protein levels in liver cancer to immunotherapy effectiveness. High NBR1 may indicate poor response to treatment, while lowering NBR1 shrinks tumors in mice.

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Chemo Plus Immunotherapy Benefits Subset of Lung Cancer Patients
Researchers have discovered that combining immunotherapy and chemotherapy can overcome treatment resistance in a subset of lung cancer patients.

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Key Genetic Factors Identified for Predicting Survival for Black Patients with Leukemia
Researchers found that specific genetic mutations in Black patients with acute myeloid leukemia (AML) significantly affect survival outcomes. Their findings stress the importance of including ancestry-specific factors in AML risk stratification.

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Cardiovascular Health Linked to Cognitive Impairments
Researchers link three common cardiovascular diseases — heart failure, atrial fibrillation and coronary heart disease — to cognitive impairment and increased risk of dementia in adults.

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Nervous System's Role in C. difficile Infections Revealed
Researchers found that the sympathetic nervous system contributes to the severity of C. difficile infections. By targeting the alpha 2 adrenergic receptor, they reduced intestinal inflammation and infection severity in lab mice.

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Cancer Drug Acts Differently Across Different Cancer Types
The chemotherapy drug 5-fluorouracil has different mechanisms of action in different cancers, a new study has found.

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Microbiome-Boosting Foods Could Help Treat Severe Malnutrition in Children
A three-month trial of a gut microbiome-directed food supplement in Bangladeshi children who suffer from malnutrition has shown that microbiome-based therapies improve growth better than a more calorically dense, commonly used supplement.

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New Blood Test Improves Early Detection of Pancreatic Cancer
An experimental blood test detects early-stage pancreatic cancer more effectively than other available tests. The findings pave are an important step toward approval as a potential diagnostic method for pancreatic cancer.

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Imaging Technique Could Lead to Earlier Diagnosis for Aggressive Kidney Cancer
UCLA researchers developed a non-invasive imaging method using 89Zr-TLX250 to detect clear-cell renal cell carcinoma. This technique demonstrated high sensitivity (85.5%) and specificity (87.0%), effectively identifying cancer in small renal masses.

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Immunotherapy-Based Cancer Treatment Proposed for Brain Metastasis
A new treatment has been proposed for immunotherapy-resistant brain metastases, with a biomarker identified that can predict cases in which it should be used.
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