Biomarkers – News and Features

Researchers have identified how autophagy and chaperone-mediated autophagy (CMA) drive the unconventional secretion of PARK7, a protein linked to Parkinson's disease. Their findings suggest new therapeutic avenues for regulating PARK7 levels.

Scientists aiming to advance cancer diagnostics have developed a machine learning tool that is able to identify metabolism-related molecular profile differences between patients with colorectal cancer and healthy people.

Researchers have discovered a set of alterations in the structure and cellular makeup of breast connective tissue – known as stromal tissue – linked to a higher risk of aggressive breast cancer and poorer survival outcomes.

The research team designed a system that converts air into liquid to facilitate detection.

A study from UC Berkeley reveals that the depths of tiny grooves on the brain’s surface, known as tertiary sulci, are linked to increased connectivity between the lateral prefrontal and parietal cortices in children and adolescents.

Explore plasma proteomics innovations tackling the dynamic range challenge, revealing biomarkers and advancing personalized medicine with Professor Joshua Coon.

A Japanese research team profiled genome-wide DNA methylation in the dorsal raphe nucleus of autism and control brains. They discovered abnormal methylation in genes related to sensory processing and serotonin signaling.

The review explores how combining radiation and immunotherapy could improve outcomes by helping the immune system detect and destroy cancer cells more effectively.

A study from the U.S. National Cancer Institute developed poly-metabolite scores based on metabolites in blood and urine to measure ultra-processed food (UPF) intake. This method offers a more reliable alternative to self-reported diet data.

A study found that foods rich in methyl adaptogens like turmeric, garlic, and berries were associated with a reduction in epigenetic age. Participants consuming these foods showed improved biological aging markers.