Biomarkers – News and Features

Researchers mapped aging across multiple organs, finding immunoglobulin G accumulation drives aging by increasing structural disorder and inflammation. The study offers IgG as a biomarker and uses antisense oligonucleotides to reduce aging effects.

Researchers at the University of Cincinnati found that copper accumulation fuels renal cell carcinoma by enhancing energy production in tumors. Elevated copper levels activate protective mechanisms that support cancer cell survival.

A new study from Charité University reveals that the biomarker Ki67 can predict if inflammatory bowel disease patients will respond to vedolizumab. Machine learning identified Ki67 levels as a marker for treatment resistance.

Using CRISPR-Cas13, NYU researchers reveal that noncoding RNAs, previously deemed “junk,” are crucial for cell function and development. Their findings, published in Cell, identify nearly 800 essential noncoding RNAs.

A team created UAB36, a polygenic score based on 36 genes linked to drug resistance, showing promise in predicting cancer treatment outcomes.UAB36 outperformed other scores, offering a potential tool for tailoring personalized cancer therapies.

Researchers identified a biomarker for schizophrenia by observing distinct neural patterns when patients faced conflicting information. This finding, measuring inflexible decision-making, could enhance diagnosis and treatment monitoring.

Researchers discovered that cordycepin, derived from the caterpillar fungus Cordyceps militaris, disrupts cancer cell growth by interfering with signaling pathways. The compound converts to cordycepin triphosphate within cells, mimicking ATP.

Researchers show that a high consumption of ultra-processed foods not only has a negative impact on general health, but could also accelerate aging itself.

Precision diagnostics for diseases that affect the brain and other organs brought closer by new ability to exclusively access contents of organ-derived extracellular vesicles in blood.

A University of Colorado study finds that prolonged sitting significantly affects health measures like cholesterol and BMI in young adults, indicating that simply meeting exercise guidelines isn't enough to offset these risks.