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Cell Culture – News and Features

A sign reading "ALS".

New Cell Culture Model Identifies Potential ALS Drug Target

Using the new cell culture model "iNets", University of Zurich researchers identified a missing link between aberrant TDP-43 behavior and neuronal cell death: a toxic accumulation of NPTX2, a protein that is usually secreted through the synapses.
A bright field image of a testicular organoid created from mouse embryos and incubated in a dish for 14 days.

“Testes in a Dish” Advance Male Fertility Research

The artificial testicles will contribute to the advancement of research in male fertility and sexual development disorders, and are expected to facilitate the eventual production of sperm in the laboratory.
Human cells.

The Need To Scale Single-Cell Functional Studies

Kathrin Herbst reviews the pros and cons of various single-cell technologies and discusses the need to move to functional readouts in the future.
Cancer cells.

Tackling Liver Metastasis and Potential Treatments

A new study has identified a crucial factor that can drive tumor cells to spread to the liver. The work points toward strategies that could help treat these often recalcitrant tumors.
Melanoma cells, with different proteins tagged in yellow, blue, green and red.

Promising Cell Therapy Target Has Strong Response Against Melanoma

A new CAR T-cell therapy that targets cells with high levels of TYRP1 has shown promise against melanoma in preclinical trials.
Two hands making a heart shape with their index and middle fingers

Could Hydrogel Help Mend a Broken Heart?

Chemical engineers are one step closer to being able to repair damaged hearts, with researchers creating a new synthetic material that accurately mimics the biomechanical properties of fibrous human tissues.
Gloved hands hold a petri dish containing cell culture.

Artificial Cartilage Produced Using 3D Printing

A high-resolution 3D printing process has been used to create scaffolds for cartilage growth, giving researchers greater control over the resulting shape.
An elderly couple looking out to sea.

Cancer Drug Could Open Doors to New Parkinson’s Treatment

A study has shown that Rucaparib and its main metabolite M324 exhibit differential activities. The paper has analyzed Rucaparib and M324, making a computational prediction of the metabolite’s activity.
Computer-generated image of cells.

Risk of Secondary Cancer Investigated After CAR T-Cell Therapy

A study by University of Pennsylvania researchers shows that secondary cancer development is rare after CAR T-cell therapy and that many patients have achieved long-lasting remission.
Stem cells.

Using Stem Cells To Enhance Cancer Immunotherapy Without Genetic Modification

A joint research team has used stem cells to generate human immune cells for application in cancer immunotherapy. This breakthrough platform is expected to significantly enhance cancer-targeting efficacy.