Cell Signaling – News and Features

UNC Lineberger researchers discovered a three-drug cocktail that enhances the production of T-memory stem cells (TSCMs) in CAR-T therapy, improving immune cell persistence and anti-tumor activity.

A study reveals a genetic signature of 177 genes shared across cancers that drives metastasis. This pan-cancer breakthrough identifies two key genes, SP1 and KLF5, influencing metastasis progression.

Targeting a protein called endocan and its related signaling pathway could be a promising new approach for treating glioblastoma.

The injection of heart muscle spheroids derived from hiPSCs can aid heart attack recovery in animal models.

Researchers have revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged.

For the first time, researchers have cultivated stable tumor organoids from circulating breast cancer cells, improving research into therapy resistance.

Rice University bioengineers have developed a new construction kit for building custom sense-and-respond circuits in human cells; representing a major breakthrough in the field of synthetic biology that could revolutionize therapies.

Texas A&M researchers found that chronic alcohol use disrupts cholinergic interneuron (CIN) firing patterns in the brain, impairing cognitive flexibility and learning. Alcohol weakens the critical "burst-pause" patterns of CINs.

A new gene therapy can reverse the effects of heart failure and restore heart function in a large animal model.

Researchers identified plasma proteins linked to brain aging using imaging and proteomics. Key biomarkers, like BCAN and GDF15, highlight early molecular signs of cognitive decline and disease risk.