Pharmacovigilance – News and Features

Researchers at the University of Alabama at Birmingham discovered that combining regorafenib with a dual JAK/HDAC inhibitor significantly improves treatment efficacy for metastatic colorectal cancer while minimizing toxic side effects.

A study analyzed data from 300,000 adults and found no evidence linking GLP-1 analogues to increased suicide, self-harm, or depression. The findings support the European Medicines Agency's conclusion.

A pilot study identified that stress, BMI, exercise, and hormonal birth control influence COVID-19 vaccine side effects. Notably, exercise impacts side effects differently between doses.

New research is the first to trace a pollutant from farming practices, nitrogen, along the U.S. beef supply chain.

A study published in JAMA Internal Medicine finds semaglutide, a weight loss medication, does not increase depressive symptoms or suicidal behavior in individuals without known mental health disorders.

New research shows a treatment plan based on novel combination of low doses of three anti-hypertensive drugs in a single pill was superior to a high-quality standard care treatment plan at lowering blood pressure.

Researchers identified new antivirulence and antibacterial compounds from actinobacteria found in the Arctic Ocean. These findings highlight the potential of antivirulence compounds as alternative treatments for bacterial infections.

Morphine is a powerful painkiller that belongs to the group of opioids. Researchers have now discovered the neural processes behind how morphine relieves pain, which is valuable knowledge due to the drug's serious side effects.

Research reveals that overgrowth of methane-producing archaea in the gut is linked to severe constipation. The study suggests that identifying and treating intestinal methanogen overgrowth (IMO) could lead to more effective, personalized treatments.

Obesity is highly prevalent among patients with CVD and significantly impacts both the course and prognosis of the condition while contributing to an increased risk of morbidity.